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CAS RN: 5983-09-5 | Product Number: D6106
2',3'-Dideoxyuridine
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Purity: >97.0%(HPLC)(qNMR)
Synonyms:
- ddU
- d2U
- 1-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$359.00
|
Contact Us | 1 | 30 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D6106 |
| Purity / Analysis Method | >97.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__4 = 212.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 5983-09-5 |
| Reaxys Registry Number | 750592 |
| MDL Number | MFCD00013359 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(qNMR) | min. 97.0 % |
| Melting point | 124.0 to 128.0 °C |
| Specific rotation | +31.0 to +35.0 deg(C=1, water) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 126 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
2',3'-Dideoxyuridine: An Inactive 2',3'-Didehydro-2',3'-Dideoxyribonucleoside against HIV
2',3'-Dideoxyuridine (ddUrd) is a 2',3'-didehydro-2',3'-dideoxyribonucleoside (ddeN). Unlike other ddeNs, ddUrd has poor anti-HIV activity.1) This is in consistent with the failure of ddUrd to be efficiently anabolized intracellularly to its 5'-triphosphate metabolite. In fact, it has been reported that 2',3'-dideoxyuridine-5'-triphosphate (ddUTP) is a potent and selective inhibitor of HIV reverse transcriptase in the cell free system.2,3) (The product is for research purpose only.)
References
- 1) The anti-HTLV-III (Anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides
- 2) Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate
- 3) Inhibition of HIV-1 replication in cultured cells with phosphorylated dideoxyuridine derivatives encapsulated in immunoliposomes
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