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CAS RN: 57808-66-9 | Product Number: D4125
Domperidone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 200MG |
$30.00
|
1 | Contact Us | 9 |
|
| 1G |
$86.00
|
2 | 1 | 3 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D4125 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4ClN__5O__2 = 425.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 57808-66-9 |
| Reaxys Registry Number | 903774 |
| PubChem Substance ID | 135727073 |
| Merck Index (14) | 3418 |
| MDL Number | MFCD00069256 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 243 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DE2275900 |
Transport Information:
| HS Number | 2933.99.7500 |
Application
Domperidone: A Peripherally Acting Dopamine D2 Receptor Antagonist
Domperidone is a peripherally acting dopamine D2 receptor antagonist with antiemetic properties similar to those of metoclopramide [M2218] . Unlike metoclopramide, however, domperidone does not readily cross the blood-brain barrier. Its antiemetic effect may be due to a combination of gastrokinetic effects and an antagonism of dopamine D2 receptor. Since the 2000s, the US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. (The product is for research purpose only.)
References
- Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity
- Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic (a review)
- Domperidone: a peripherally acting dopamine2-receptor antagonist (a review)
- Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine (a review)
- High-performance liquid chromatographic analysis for the determination of domperidone in human plasma
- Simultaneous estimation of paracetamol and domperidone in tablets by reverse phase HPLC method
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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