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CAS RN: 133052-90-1 | Product Number: B5781
Bisindolylmaleimide I
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Purity: >97.0%(HPLC)
Synonyms:
- GF 109203X
- 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5MG |
$86.00
|
Contact Us | Contact Us | 7 |
|
| 25MG |
$297.00
|
Contact Us | Contact Us | 31 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B5781 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__4N__4O__2 = 412.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 133052-90-1 |
| Reaxys Registry Number | 7952743 |
| PubChem Substance ID | 468590702 |
| MDL Number | MFCD00236428 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 268.0 to 272.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 270 °C |
| Maximum Absorption Wavelength | 466(EtOH) nm |
GHS
Related Laws:
| RTECS# | UX9590000 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
Bisindolylmaleimide I: A Potent, Selective and Competitive Inhibitor of Protein Kinase C (PKC)
Protein kinase C (PKC) isoforms, a family of serine/threonine protein kinases, are thought to mediate numerous signal transduction processes including the control of cell growth, differentiation and homeostasis. Bisindolylmaleimide I (GF 109203X) a potent, selective and competitive inhibitor of PKC isoforms.1-3) Bisindolylmaleimide I (GF 109203X) also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.4) (The product is for research purpose only.)
References
- 1) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
- 2) The protein kinase C inhibitors Ro318220 and GF109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70S6 kinase
- 3) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
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