Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 327036-89-5 | Product Number: B4436
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
- TDZD-8
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5MG |
$88.00
|
1 | 1 | 37 |
|
| 25MG |
$265.00
|
Contact Us | Contact Us | 36 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4436 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0N__2O__2S = 222.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 327036-89-5 |
| Reaxys Registry Number | 8763878 |
| PubChem Substance ID | 354334062 |
| MDL Number | MFCD04973552 |
Specifications
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.00 to 13.00 % |
| Melting point | 61.0 to 65.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 63 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P280 : Wear protective gloves. P272 : Contaminated work clothing must not be allowed out of the workplace. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse. |
Related Laws:
Transport Information:
| HS Number | 2934.99.4400 |
Application
TDZD-8: An ATP Noncompetitive GSK-3β Inhibitor
Thiadiazolidinone-8 (TDZD-8) is an ATP noncompetitive glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50=2 µM). TDZD-8 is selective against GSK-3β, and has minimal inhibitory effect observed on cyclin-dependent kinase 1 (CDK1), casein kinase II, protein kinase A (PKA). However, it is also reported that TDZD-8 can inhibit the protein kinase C (PKC). Besides, it is reported that TDZD-8 has anti-leukemia activity in leukemia cells, and effects against Alzheimer's disease. (The product is for research purpose only.)
References
- On the Role of Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and Glycogen Synthase Kinase-3β in Photodynamic Injury of Crayfish Neurons and Glial Cells
- First Non-ATP Competitive Glycogen Synthase Kinase 3β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease
- Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
- SAR and 3D-QSAR Studies on Thiadiazolidinone Derivatives: Exploration of Structural Requirements for Glycogen Synthase Kinase 3 Inhibitors
Application
Glycogen Synthase Kinase (GSK) Inhibitor
References
- 1)Glycogen synthase kinase-3 from rabbit skeletal muscle, separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
- 2)Molecular cloning and expression of glycogen synthase kinase-3/Factor A
- 3)GSK-3: Tricks of the trade for a multi-tasking kinase
- 4)Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging
- 5)First non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer’s disease
- 6)Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.