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CAS RN: 153254-09-2 | Product Number: B3022
2,4-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
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Purity:
Synonyms:
- 2,4-Bis(trifluoromethyl)benzeneboronic Acid (contains varying amounts of Anhydride)
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$46.00
|
Contact Us | 2 | Contact Us |
|
| 5G |
$103.00
|
1 | Contact Us | 36 |
|
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| Product Number | B3022 |
| Molecular Formula / Molecular Weight | C__8H__5BF__6O__2 = 257.93 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 153254-09-2 |
| Reaxys Registry Number | 10175108 |
| PubChem Substance ID | 87559527 |
| MDL Number | MFCD01631349 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(Neutralization titration) | 97.0 to 108.0 % |
Properties (reference)
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2931.90.6000 |
Application
TCI Practical Example: Condensation Reaction Utilizing the Boronic Acid Catalyst
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Used Chemicals
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Procedure
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To a solution of benzoic acid (122 mg, 1.0 mmol) and benzylamine (107 mg, 1.0 mmol) in fluorobenzene (5 mL, 0.2 mol/L) was added molecular sieves 3A (2 g) at room temperature. After that 2,4-bis(trifluoromethyl)phenylboronic acid (13 mg, 0.05 mmol) was added to the reaction mixture and stirred at reflux temperature for 24 hours. The reaction mixture was filtered on celite pad and washed with EtOAc. The filtrate was washed with 2 mol/L HCl aq. (30 mL), saturated NaHCO3 aq. (30 mL), and brine (30 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to give N-benzylbenzamide as a white solid (135 mg, 64%).
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Experimenter’s Comments
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The reaction mixture was monitored by LC.
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Analytical Data
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N-benzylbenzamide
1H NMR (270 MHz, DMSO-d6); δ 9.05 (brt, 1H, J = 5.4 Hz), 7.90 (dd, 1H, J = 7.3, 1.6 Hz), 7.56-7.44 (m, 3H), 7.36-7.32 (m, 4H), 7.25 (q, 1H, J = 7.3 Hz).
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Lead Reference
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- The ortho-substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines
PubMed Literature
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Safety Data Sheet (SDS)
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Specifications
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