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CAS RN: 229975-97-7 | Product Number: A3411
Atazanavir Sulfate
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Purity: >98.0%(HPLC)
Synonyms:
- Dimethyl (3S,8S,9S,12S)-9-Benzyl-3,12,di-tert-butyl-8-hydroxy-4,11-dioxo-6-(p-2-pyridylbenzyl)-2,5,6,10,13-pentaazatetradecanedioate Sulfate
- Methyl [(5S,8S,9S,14S)-8-Benzyl-5-(tert-butyl)-9-hydroxy-15,15-dimethyl-3,6,13-trioxo-11-[4-(pyridin-2-yl)benzyl]-2-oxa-4,7,11,12-tetraazahexadecan-14-yl]carbamate Sulfate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$167.00
|
Contact Us | Contact Us | 3 |
|
| 500MG |
$499.00
|
Contact Us | Contact Us | 10 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3411 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__8H__5__2N__6O__7·H__2SO__4 = 802.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 229975-97-7 |
| Reaxys Registry Number | 11331446 |
| PubChem Substance ID | 468590285 |
| MDL Number | MFCD08067748 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -44.0 to -48.0 deg(C=1, H2O:MeOH=1:1) |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H318 : Causes serious eye damage. |
| Precautionary Statements | P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | RY8794000 |
Transport Information:
| HS Number | 2933.39.4100 |
Application
Atazanavir Sulfate: An Azapeptide HIV-1 Protease Inhibitor
Atazanavir sulfate (BMS-232632) is s an azapeptide protease inhibitor with high specificity for, and activity against HIV-1 protease. Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. For the treatment of HIV-1 infection, atazanavir is recommended in combination with other antiretroviral agents such as ritonavir [R0116], a pharmacokinetic enhancer (booster). (The product is for research purpose only.)
References
- BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents
- Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors
- Atazanavir: A review of its use in the management of HIV-1 infection
- Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults (a review)
- New validated RP-HPLC method for the determination of atazanavir sulphate in bulk and dosage form
- Determination of atazanavir and other antiretroviral drugs (indinavir, amprenavir, nelfinavir and its active metabolite M8, saquinavir, ritonavir, lopinavir, nevirapine and efavirenz) plasma levels by high performance liquid chromatography with UV detection
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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