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CAS RN: 909910-43-6 | Product Number: A3324
A 83-01
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Purity: >95.0%(HPLC)
Synonyms:
- 3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
- 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5MG |
$49.00
|
Contact Us | 1 | Contact Us |
|
| 25MG |
$180.00
|
Contact Us | Contact Us | 3 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A3324 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__1__9N__5S = 421.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 909910-43-6 |
| Reaxys Registry Number | 15627575 |
| PubChem Substance ID | 468590236 |
| MDL Number | MFCD08705403 |
Specifications
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933.49.7000 |
Application
A Thioamide for the Potent Inhibition of TGF-β Signaling
Reference
- The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β
- TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion
- Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
Application
A 83-01: A Potent Inhibitor of Activin Receptor-Like Kinase 4/5/7 (ALK4/5/7)
Transforming growth factor (TGF)-β signaling facilitates tumor growth and metastasis in advanced cancer. A 83-01 has been reported to be an inhibitor of TGF-β type I receptor kinase (ALK5), activing type IB receptor (ALK4), and nodal type I receptor (ALK7), respectively.1) Furthermore, A 83-01 has been used to reprogram fibroblasts into alternative lineages, such as cardiomyocyte-like cells.2) Therefor, A 83-01 is thought to affect stem cell differentiation and tumor progression in animal models.3)
References
- 1) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β
- 2) Conversion of human fibroblasts into functional cardiomyocytes by small molecules
- 3) Perspectives of small molecule inhibitors of activin receptor.like kinase in anti.tumor treatment and stem cell differentiation (Review)
Articles/Brochures
TCIMAIL
[Product Highlights] A Thioamide for the Potent Inhibition of TGF-β Signaling[TCIMAIL No.193] Activin Receptor-Like Kinase (ALK) 4/5/7 Inhibitor
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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