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CAS RN: 661489-23-2 | Product Number: A2982
(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride
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Purity: >98.0%(N)
Synonyms:
- (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$155.00
|
1 | 1 | 2 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A2982 |
| Purity / Analysis Method | >98.0%(N) |
| Molecular Formula / Molecular Weight | C__1__1H__1__2N__2·HCl = 208.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 661489-23-2 |
| Reaxys Registry Number | 11416007 |
| PubChem Substance ID | 354334826 |
| MDL Number | MFCD18711816 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 300 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2926.90.4801 |
Application
A Key Synthetic Intermediate of Rilpivirine
This product is a key synthetic intermediate of rilpivirine which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of HIV.
References
- Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate
- Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
- d. P. R. Schils, J. J. M. Willems, B. P. A. M. J. Medaer, E. T. J. Pasquier, J. Heeres, R. G. G. Leenders, J. E. G. Guillemont, P. A. J. Janssen, World Intellectual Property Organization WO 2004/016581 A1.
- A validated stability indicating HPLC assay method for rilpivirine HCl in bulk drug
Application
A Synthetic Building Block of Rilpivirine
This compound is a key synthetic building block of rilpivirine [CAS: 500287-72-9] which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV infection.
References
- Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate
- A validated stability indicating HPLC assay method for rilpivirine HCl in bulk drug
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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