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CAS RN: 446-86-6 | Product Number: A2069
Azathioprine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$175.00
|
Contact Us | 3 | 32 |
|
| 25G |
$524.00
|
Contact Us | Contact Us | 1 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A2069 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__7N__7O__2S = 277.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 446-86-6 |
| Reaxys Registry Number | 1225351 |
| PubChem Substance ID | 87559964 |
| Merck Index (14) | 902 |
| MDL Number | MFCD00069203 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 244 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UO8925000 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
Biofilm research
Reference
- The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability
Application
Azathioprine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis
Azathioprine, a prodrug of 6-mercaptopurine (6-MP) [M0063], was developed by Elion and Hitchings as an immunosuppressant agent for renal transplantation in 1962. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine and 6-MP are commonly used as an immunosuppressant for treatment of rheumatism, Crohn’s disease and inflammatory bowel disease. (The product is for research purpose only.)
References
- Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues
- Optimisation of Azathioprine Immunosuppression after Organ Transplantation by Pharmacological Measurements
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- Azathioprine: old drug, new actions (a review)
- Thiopurine Therapies: Problems, Complexities, and Progress with Monitoring Thioguanine Nucleotides
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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