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CAS RN: 51-55-8 | Product Number: A0754
Atropine
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Purity: >99.0%(T)
Synonyms:
- (±)-Hyoscyamine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$142.00
|
12 | 2 | 34 |
|
| 25G |
$488.00
|
1 | 1 | 25 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A0754 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__1__7H__2__3NO__3 = 289.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 51-55-8 |
| Reaxys Registry Number | 91256 |
| PubChem Substance ID | 87562295 |
| SDBS (AIST Spectral DB) | 7817 |
| Merck Index (14) | 875 |
| MDL Number | MFCD00022622 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 114.0 to 118.0 °C |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 116 °C |
| Degree of solubility in water | 2.2 g/l 25 °C |
| Solubility (soluble in) | Methanol, Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H331 : Toxic if swallowed or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | CK0700000 |
Transport Information:
| UN Number (DOT-AIR) | UN1544 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2939.79.0000 |
Application
Atropine: A Nonselective Muscarinic Acetylcholinergic Receptors Antagonist
Atropine, a tropane alkaloid, is a free base of its sulfate [A0550] which was first extracted from the root of belladonna (Atropa belladonna) in 1830s. Atropine is a enantiomeric mixture of (R,S)-hyoscyamine (dl-hyoscyamine), racemization occurring during the extraction procedure, whereas only (S)-hyoscyamine (l-hyoscyamine) [H0450] is the active isomer. Atropine is a competitive antagonist of muscarine-like actions of acetylcholine and is therefore classified as an antimuscarinic agent. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors. Atropine inhibits the action of acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system. (The product is for research purpose only.)
References
- Muscarinic antagonists in development for disorders of smooth muscle function (a review)
- Atropine (a review on the chemical and physical properties, isolation, synthesis, methods of analysis, and pharmacology of atropine)
- High-performance liquid chromatographic determination of atropine and atropine-like alkaloids in pharmaceutical preparations with indirect conductometric detection
- Determination of atropine in pharmaceutical preparations by liquid chromatography with fluorescence detection
- Analysis of atropine, its degradation products and related substances of natural origin by means of reversed-phase high-performance liquid chromatography
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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