text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

请选择数量

Cross-coupling Reactions Using Organosodium

Takai et al. have reported a simple preparation of organosodium compounds 1 using sodium dispersion and their subsequent application for cross-coupling reactions. 1 transmetallates with zinc and boron to provide organozinc intermediate compounds via a reaction with ZnCl2-TMEDA and organoboron compounds via a reaction with methoxyboronic acid pinacol ester, respectively. These intermediates can be applied to Negishi and Suzuki-Miyaura cross-coupling reactions in one-pot manner. In addition, direct cross-coupling of arylsodiums and arylhalides can be achieved. The preparation of organosodium compounds using sodium dispersion has several advantages such as easier utilization of inexpensive organic chlorides as starting materials and mild reaction conditions (0-30 ºC) compared to the synthesis of conventional organolithiums or organomagnesiums which require harsher or more specific and sensitive substrates.

D5792_D4393_M1714_1

Related Products

D5792
Sodium Dispersion
D4393
ZnCl2-TMEDA
M1714
Methoxyboronic Acid Pinacol Ester

References

會話狀態
當前會話將在10分鐘後超時,並返回主頁。請點擊按鈕繼續瀏覽。分鐘後超時,並返回主頁。請點擊按鈕繼續瀏覽。

您的會話已超時,將返回至主頁。