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CAS RN: 139180-30-6 | 產品號碼: Z0042
ZM 241385
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* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準,敬請留意。
產品號碼 | Z0042 |
純度/分析方法 | >95.0%(HPLC)(qNMR) |
分子式 / 分子量 | C__1__6H__1__5N__7O__2 = 337.34 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive,Heat Sensitive |
CAS RN | 139180-30-6 |
Reaxys-RN | 8162461 |
MDL編號 | MFCD00908394 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Purity(qNMR) | min. 95.0 % |
Melting point | 225.0 to 229.0 °C |
NMR | confirm to structure |
性質
熔點 | 227 °C |
GHS
相關法規
RTECS # | SJ6064000 |
運輸資料
HS編碼* | 2934.99-000 |
Application
ZM 241385: A Potent A2A Adenosine Receptor (A2AR) Antagonist
The A2A adenosine receptor (A2AR) is a G protein-coupled receptor (GPCR) belonging to the P1/adenosine receptor (AR) family, which also includes the A1, A2B and A3 receptor subtypes. ARs play a central role in a wide range of physiological processes, including sleep regulation, angiogenesis and modulation of the immune system.1,2) A2AR has been reported to play a role in the regulation of myocardial coronary blood flow, sleep regulation, angiogenesis and immunosuppression. Thus, ZM 241385 is a potent A2AR antagonist and has been used as a tool in many pharmacological studies.2-4) (The product is for research purpose only.)
References
- Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation (a review)
- The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
- The in vitro pharmacology of ZM 241385, a potent, non-xanthine, A2A selective adenosine receptor antagonist
- Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors
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