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CAS RN: 288250-47-5 | 產品號碼: Y0019
| 產品號碼 | Y0019 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__7H__2__9ClN__6O__2 = 505.02 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| CAS RN | 288250-47-5 |
| Reaxys-RN | 13170463 |
| PubChem Substance ID | 468593134 |
| MDL編號 | MFCD28099803 |
產品規格
| Appearance | Light yellow to Brown powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 260 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
Y-320: An Inhibitor of the Release of IL-17 by CD4 T Cells
Y-320 is an orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits interleukin 17 (IL-17) production by CD4 T cells stimulated with IL-15 which is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis.1) Recently, there is a report that Y-320 can be used as a read-through agent for the treatment of genetic diseases caused by premature termination codons (PTC). 2) (The product is for research purpose only.)
References
- 1) A new phenylpyrazoleanilide, Y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys
- 2) Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough
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