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CAS RN: 69388-84-7 | 產品號碼: U0159
Sulbactam Sodium
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| 產品號碼 | U0159 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__8H__1__0NNaO__5S = 255.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 69388-84-7 |
| Reaxys-RN | 3599871 |
| MDL編號 | MFCD01750374 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | +219 to +233 deg(C-1, water) |
| Water | max. 1.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 190 °C |
GHS
相關法規
| RTECS # | XH9220000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Sulbactam Sodium: A β-Lactamase Inhibitor Used with Another Antibiotic
Sulbactam [S0868] and its sodium salt are β-lactamase inhibitors which are chemically synthesized from 6-APA [A0800]. Although they have low antimicrobial activity, they inhibit enzymes (β-lactamases) which are produced by bacteria to degrade β-lactam antibiotics such as penicillins and cephalosporins. They are often used in combination with amoxicillin [A2099] or cefoperazone [C2768] to increase the antibiotic spectrum of theirs. (The product is for research purpose only.)
References
- Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases
- A Structure-Based Analysis of the Inhibition of Class A β-Lactamases by Sulbactam
- Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics (a review)
- Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations (a review)
- Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition (a review)
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