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CAS RN: 83105-70-8 | 產品號碼: U0097
Sultamicillin Tosylate Dihydrate
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| 產品號碼 | U0097 |
| 純度/分析方法 | >98.0%(GC)(T) |
| 分子式 / 分子量 | C__2__5H__3__0N__4O__9S__2·C__7H__8O__3S·2H__2O = 802.88 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 83105-70-8 |
| 相關CAS RN | 76497-13-7 |
| Reaxys-RN | 25499733 |
| PubChem Substance ID | 354335315 |
| Merck Index(14) | 8992 |
| MDL編號 | MFCD01682151 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +168 to +186 deg(C=0.5, water/CH3CN 3:2) |
性質
| 比旋光 [α]D | 177° (C=0.5,H2O/HcN=3:2) |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Ethanol, Methanol |
GHS
相關法規
| RTECS # | XH8460000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Sultamicillin Tosylate: The Mutual Prodrug of Ampicillin and Sulbactam
Sultamicillin tosylate is a double ester mutual prodrug in which ampicillin [A2092] and the β-lactamase inhibitor sulbactam [S0868] are linked via a methylene group. Sultamicillin is readily absorbed and hydrolyzed by enzymes in the intestinal wall, releasing ampicillin and sulbactam. Ampicillin is an aminopenicillin which exerts its bactericidal activity by inhibiting transpeptidase, an enzyme responsible for the synthesis of the peptidoglycan layer of the bacterial cell wall. Sulbactam is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases, produced by resistant bacteria. Therefore, sultamicillin is effective against a wide range of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis, including penicillin-resistant and some methicillin-resistant strains. (The product is for research purpose only.)
References
- Sultamicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use
- Role of sultamicillin and ampicillin/sulbactam in the treatment of upper and lower bacterial respiratory tract infections (a review)
- HPLC determination of sulbactam, sultamicillin tosylate, cefaclor, ampicillin and cefoperazone in pharmaceutical preparations
- Quantitative determination of sultamicillin p-toluenesulfonate in pharmaceutical preparations by reversed-phase high-performance liquid chromatography
- HPLC for in-process control in the production of sultamicillin
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