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CAS RN: 33005-95-7 | 產品號碼: T3175
Tiaprofenic Acid
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產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 96.0 to 100.0 °C |
性質
| 熔點 | 99 °C |
| Maximum Wavelength | 314(Phosphate buffer sol.) nm |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | XM7580000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2934.99-000 |
Application
Tiaprofenic acid: A NSAID of the 2-Arylpropionic Acid Class.
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid (2-APA) class. The S-enantiomer possessing most of the beneficial anti-inflammatory activity. Tiaprofenic acid and the other 2-APAs (eg: carprofen [C2701], naproxen [M1021] and ketoprofen [K0038]) have been reported their photosensitizing side effects caused by their photodegradation products.
References
- 1)Tiaprofenic acid: A reappraisal of its pharmacological properties and use in the management of rheumatic diseases
- 2)Clinical pharmacokinetics of tiaprofenic acid and its enantiomers
- 3)Photoreactivity of the nonsteroidal anti-inflammatory 2-arylpropionic acids with photosensitizing side effects (a review)
- 4)Tiaprofenic acid-photosensitized damage to nucleic acids: a mechanistic study using complementary in vitro approaches
- 5)High-performance liquid chromatographic assay of ketoprofen enantiomers in human plasma and urine
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