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CAS RN: 119413-54-6 | 產品號碼: T2795
Topotecan Hydrocholoride
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| 產品號碼 | T2795 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__3H__2__3N__3O__5·HCl = 457.91 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 119413-54-6 |
| Reaxys-RN | 5470704 |
| PubChem Substance ID | 468592816 |
| Merck Index(14) | 9548 |
| MDL編號 | MFCD00866235 |
產品規格
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0% (calcd. on anh. substance) |
| Specific rotation | 100 to 105 deg(C=0.5, water, calcd.on anh.substance) |
| Water | max. 12.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 215 °C(dec.) |
| Maximum Wavelength | 414(Phosphate buffer sol.) nm |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | UQ0491400 |
運輸資料
| HS編碼* | 2939.79-000 |
Application
Topotecan Hydrocholoride: A Water-Soluble Topoisomerase I Inhibitor
Topotecan hydrocholoride is a topoisomerase I inhibitor that is a semi-synthetic water-soluble derivative of camptothecin [C1495].1) During the course of its normal cell cycle, topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks, and transiently forms a covalent bond with DNA. Topotecan prevents the re-ligation of these single-strand breaks by binding to and stabilizing the complex of topoisomerase I and DNA. This process leads to breaks in the DNA strand resulting in apoptosis and cell death.1-3) Recently, lipid nanoencapsulation of topotecan has attracted much attention in order to reduce the loss of efficacy of topotecan due to its hydrolysis in vivo4). (The product is for research purpose only.)
References
- 1) Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity
- 2) Topotecan, a novel topoisomerase I inhibitor. Pharmacology and clinical experience (a review)
- 3) The mechanism of topoisomerase I poisoning by a camptothecin analog
- 4) Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release
- 5) Development and validation of a liquid chromatography-tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study
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