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CAS RN: 6809-52-5 | 產品號碼: T2701
Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]
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產品規格
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 95.0 %(total of isomer) |
性質
| 沸點 | 160 °C/0.01 mmHg |
| 比重 | 0.89 |
| 折射率 | 1.49 |
GHS
相關法規
| RTECS # | RA5391300 |
運輸資料
| HS編碼* | 2914.19-000 |
Application
Teprenone: An Agent with Potent Effects for Gastritis and Ulcers
Teprenone (or geranylgeranylacetone, GGA) has been demonstrated to show a potent anti-ulcer effect against various ulcers. Teprenone also promotes mucus synthesis and secretion in cultured gastric mucosal epithelial cells, and increases of gastric mucosal prostaglandins. Recently, teprenone has been shown to induce heat shock proteins (HSPs) in various cell types and to protect cells from apoptogenic insults. (The product is for research purpose only.)
References
- Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl
- Geranylgeranylacetone, a Novel Anti-Ulcer Drug, Stimulates Mucus Synthesis and Secretion in Rat Gastric Cultured Cells
- Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
- Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart
- Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70
- Pharmacological targeting of the Hsp70 chaperone (a review)
考研文獻
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