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CAS RN: 54965-24-1 | 產品號碼: T2510
Tamoxifen Citrate
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| 產品號碼 | T2510 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__6H__2__9NO·C__6H__8O__7 = 563.65 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Hygroscopic,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 54965-24-1 |
| 相關CAS RN | 10540-29-1 |
| Reaxys-RN | 8888650 |
| PubChem Substance ID | 87560062 |
| Merck Index(14) | 9048 |
| MDL編號 | MFCD00058321 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 142 °C(dec.) |
| 水溶性 | Slightly soluble |
| 溶解性（可溶於） | Ethanol, Acetone, Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | KH2387000 |
運輸資料
| HS編碼* | 2921.49-000 |
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen [H1693] and endoxifen (4-hydroxy-N-desmethyltamoxifen). Each acts as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, raloxifene, and the prevention of breast cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen and endoxifen (4-hydroxy-N-desmethyltamoxifen). They act as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, Raloxifene, and the Prevention of Breast Cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
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