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CAS RN: 738-70-5 | 產品號碼: T2286
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 199.0 to 205.0 °C |
| Solubility in hot Methanol | almost transparency |
| NMR | confirm to structure |
性質
| 熔點 | 202 °C |
| 水溶性 | Insoluble |
| Degree of solubility in water | 400 mg/l 25 °C |
| 溶解性（微溶於） | Methanol, Chloroform |
| 溶解性（不溶於） | Benzene, Ether |
GHS
相關法規
| RTECS # | UV8225000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
Trimethoprim: A Synthetic Antibiotic Agent Inhibiting Dihydrofolate Reductase
Trimethoprim, a synthetic antibiotic agent, exerts antimicrobial activity by blocking the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. In addition, some combination agents with the other antimicrobials (e.g.: sulphamethoxazole [S0361], daptomycin [D4229] and polymyxin B [P1923]) are widely used for the treatment of infections including MRSA infection. (The product is for research purpose only.)
References
- Trimethoprim: mechanisms of action, antimicrobial activity, bacterial resistance, pharmacokinetics, adverse reactions, and therapeutic indications (a review)
- Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections
- Trimethoprim/sulfonamide combinations in the horse: A review
- Trimethoprim and sulfonamide resistance (a review)
- Evaluation of the novel combination of high-dose daptomycin plus trimethoprim-sulfamethoxazole against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus using an in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations
- Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry
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