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CAS RN: 60491-10-3 | 產品號碼: S0094
Strychnine Sulfate Pentahydrate
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| 產品號碼 | S0094 |
| 純度/分析方法 | >97.0%(T) |
| 分子式 / 分子量 | C__4__2H__4__4N__4O__4·H__2SO__4·5H__2O = 856.99 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 60491-10-3 |
| 相關CAS RN | 60-41-3 |
| Reaxys-RN | 8179430 |
| PubChem Substance ID | 87575709 |
| Merck Index(14) | 8855 |
| MDL編號 | MFCD00068328 |
產品規格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 97.0 %(calcd.on dried substance) |
| Solubility in hot Water | almost transparency |
| Drying loss | 10.5 to 13.0 % |
| NMR | confirm to structure |
性質
| 水溶性 | Soluble |
| Degree of solubility in water | 29 g/l |
| 溶解性（微溶於） | Alcohol |
| 溶解性（不溶於） | Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 + H330 : Fatal if swallowed or if inhaled. H410 : Very toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | WL2550000 |
運輸資料
| UN編號 | UN1692 |
| 類別 | 6.1 |
| 包裝類別 | I |
| HS編碼* | 2939.79-000 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
考研文獻
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