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CAS RN: 6533-68-2 | 產品號碼: S0021
Scopolamine Hydrobromide Trihydrate
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| 產品號碼 | S0021 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__7H__2__1NO__4·HBr·3H__2O = 438.32 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 6533-68-2 |
| 相關CAS RN | 114-49-8&51-34-3 |
| Reaxys-RN | 6100669 |
| PubChem Substance ID | 87575651 |
| Merck Index(14) | 8406 |
| MDL編號 | MFCD00012647 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(after drying) |
| Specific rotation [a]20/D | -24.0 to -27.0 deg(C=5, H2O)(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 13.0 % |
性質
| 熔點 | 195 °C |
| 比旋光 [α]D | -25.5° (C=5,H2O) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | YM4550000 |
運輸資料
| UN編號 | UN1544 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2939.79-000 |
Application
Scopolamine Hydrobromide: A Belladonna Alkaloid with Anticholinergic Activity
Scopolamine salts ([S0021][ S0230] and [S0231]) and N-oxide [S0229], belladonna alkaloids, are anticholinergic agents. Their free base, scopolamine competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine [A0754] as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al. (The product is for research purpose only.)
References
- The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies (a review)
- Analytical profile of scopolamine hydrobromide (a review on description, synthesis, physical properties, analytical stability and storage, pharmacology, and pharmacokinetics)
- HPLC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals
- Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry
Application
Reagent for experimental amnesia (Alzheimer's disease) model
References
- Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat
- Scopolamine as an antidepressant: a systematic review
- Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review
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