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CAS RN: 90098-04-7 | 產品號碼: R0085
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
性質
| 熔點 | 290 °C(dec.) |
GHS
相關法規
| RTECS # | VC2518500 |
運輸資料
| HS編碼* | 2933.49-000 |
Application
Rebamipide: A Quinolinone Analog for Gastric Mucosal Protection
Rebamipide (OPC-12759), a 2(1H)-quinolinone analog, is used as an anti-gastritis and anti-gastric ulcer agent. It has been reported to have various activities in the gastric mucosa, such as stimulation of prostaglandin and mucus glycoprotein synthesis, inhibition of reactive oxygen species, inflammatory cytokines and chemokines, and inhibition of neutrophils activation. Furthermore, inhibition of gastric tumor growth by rebamipide has also been reported. In addition, rebamipide is used as a therapeutic adjunct for the treatment of infections caused by Helicobacter pylori. For your reference, we also have a related synthetic intermediate [O0468] of rebamipide. (The product is for research purpose only.)
References
- Studies on 2 (1H)-Quinolinone Derivatives as Gastric Antiulcer Active Agents. 2-(4-Chlorobenzoylamino)-3-[2 (1H)-quinolinon-4-yl] propionic Acid and Related Compounds
- Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat
- Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study
- 15th Anniversary of Rebamipide: Looking Ahead to the New Mechanisms and New Applications (a review)
- Rebamipide: a gastrointestinal protective drug with pleiotropic activities (a review)
- Optimization of forced degradation using experimental design and development of a stability-indicating liquid chromatographic assay method for rebamipide in bulk and tablet dosage form
Application
Induction of Cyclooxygenase-2 (COX-2) in Rat Gastric Mucosa by Rebamipide
Reference
- Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
- M. Yasumaru, H. Iijima, Y. Okuda, Y. Sasaki, M. Hori, S. Kawano, J. Pharmacol. Exp. Ther. 2000, 295, 447.
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