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CAS RN: 6119-47-7 | 產品號碼: Q0030
Quinine Hydrochloride Dihydrate
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產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 90.0 area% |
Purity(Nonaqueous Titration) | 98.0 to 105.0 % |
Specific rotation [a]20/D | -245 to -255 deg(C=2, 0.1mol/l HCl(calcd.on dried substance) |
Solubility in hot Water | almost transparency |
Drying loss | max. 10.0 % |
性質
熔點 | 160 °C |
比旋光 [α]D | -250° (C=2,0.1mol/L HCl) |
GHS
圖形表示 | |
信號詞 | Danger |
危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | VA7700000 |
運輸資料
HS編碼* | 2939.20-000 |
Application
Quinine: An Antimalarial Substance
Quinine is one of the alkaloids which is included in the bark of cinchona tree and has been researched since 19th century.1) It has an anti-malarial activity2-4) and is considered to inhibit heme polymerase of plasmodium and to indicate toxicity to plasmodium. (The product is for research purpose only)
References
- 1) Fatal Dose of Sulphate of Quinine
- 2) Antimalarial Drug Toxicity (a review)
- 3) Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications (a review)
- 4) Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria (a review)
- 5) Quinine hydrochloride (a review on the physical properties, synthesis, biosynthesis, metabolism and pharmacokinetics, indications and dosages, toxicity and methods of determination)
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