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CAS RN: 74150-27-9 | 產品號碼: P2779
產品號碼 | P2779 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__1__9H__1__8N__4O__2 = 334.38 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive,Heat Sensitive |
包裝和容器 | 250MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 74150-27-9 |
Reaxys-RN | 4207330 |
PubChem Substance ID | 468592720 |
MDL編號 | MFCD00761648 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
NMR | confirm to structure |
性質
熔點 | 249 °C(dec.) |
GHS
圖形表示 | |
信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | UR6373000 |
運輸資料
HS編碼* | 2933.99-000 |
Application
A Benzimidazole-Pyridazinone Derivative with Phosphodiesterase (Type III) Inhibition and Calcium-Sensitizing Properties
Pimobendan, a benzimidazole-pyridazinone derivative, is used as a veterinary cardiotonic vasodilator. It has been reported that pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (Type III). (The product is for research purpose only.)
References
- Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties
- Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure (a review)
- Mechanisms of action of calcium-sensitizing drugs (a review)
- Mechanism of action of Ca2+ sensitizers - Update 2001
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