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CAS RN: 171228-49-2 | 產品號碼: P2477
| 產品號碼 | P2477 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__3__7H__4__2F__2N__8O__4 = 700.79 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 10MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 171228-49-2 |
| Reaxys-RN | 8379448 |
| PubChem Substance ID | 354335523 |
| Merck Index(14) | 7602 |
| MDL編號 | MFCD00941162 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 167.0 to 171.0 °C |
| Specific rotation [a]20 | -24.0 to -28.0 deg(C=1, CHCL3) |
性質
| 熔點 | 169 °C |
| 比旋光 [α]D | -26° (C=1,CHCl3) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | XZ5481020 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Posaconazole: An Triazole Antifungal Agent with Broad-Spectrum Activity
Posaconazole (SCH 56592), an triazole antifungal agent with broad-spectrum activity, appears to inhibit ergosterol synthesis of fungi by inhibiting the enzyme lanosterol 14 α-demethylase. Inhibition of this enzyme’s activity by posaconazole results in decreased amounts of ergosterol, a constituent of fungal cell membranes. Especially, posaconazole has broader spectrum of activity than other available antifungals. Posaconazole has even activity against Aspergillus fumigatus and Candida albicans refractory to other triazole antifungal agents, such as itraconazole [I0732] or fluconazole [F0677]. (The product is for research purpose only.)
References
- Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts
- Three-dimensional models of wild-type and mutated forms of cytochrome P450 14α-sterol demethylasesfrom Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding
- Posaconazole: A broad-spectrum triazole antifungal (a review)
- Posaconazole: Clinical pharmacology and potential for management of fungal infections (a review)
- Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection
- Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin
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