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CAS RN: 14222-60-7 | 產品號碼: P2302
產品規格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 141.0 to 145.0 °C |
性質
| 熔點 | 143 °C |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | NS0650000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Prothionamide: A Thioamide Anti-Tuberculosis Agent
Prothionamide and ethionamide [E0695] are thioamide anti-tuberculosis agents. They have activity against Mycobacterium tuberculosis, Mycobacterium leprae murium and Mycobacterium avium. The precise mechanisms of action remain unknown, but it has been reported that the thioamides are prodrugs that are oxidatively converted to their active forms by the flavin monooxygenase EtaA of Mycobacterium tuberculosis.
References
- Mechanism of thioamide drug action against tuberculosis and leprosy
- Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases (a review)
- High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids
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