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CAS RN: 137281-23-3 | 產品號碼: P2288
| 產品號碼 | P2288 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__1N__5O__6 = 427.42 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 137281-23-3 |
| 相關CAS RN | 1916503-69-9 |
| Reaxys-RN | 9097855 |
| PubChem Substance ID | 253661102 |
| Merck Index(14) | 7077 |
| MDL編號 | MFCD19105065 |
產品規格
| Appearance | White to Blue powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | 2.0 to 11.0 % |
性質
| 溶解性（微溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | LZ9950100 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Pemetrexed: A Multitargeted Antifolate
Pemetrexed is an antimetabolite that inhibits at least three enzymes involved in the folate pathway. These enzymes are thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT) which are used in purine and pyrimidine synthesis. Therefore, pemetrexed prevents the formation of DNA and RNA which are required for the growth of both normal cells and tumor cells. Pemetrexed has demonstrated clinical activity in non-small cell lung cancer and mesothelioma as well as in a broad array of other solid tumors. For your reference, [A2618] and [M2426] are key synthetic intermediates of pemetrexed. (The product is for research purpose only.)
References
- A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase
- Pemetrexed: A multitargeted antifolate (a review)
- Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications (a review)
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