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CAS RN: 189028-93-1 | 產品號碼: P2111
(S)-4-Phenyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-2-oxazolidinone
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![(S)-4-Phenyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-2-oxazolidinone](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "(S)-4-Phenyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-2-oxazolidinone")
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產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 90.0 to 94.0 °C |
| Specific rotation [a]20/D | +49.0 to +54.0 deg(C=0.2, CHCL3) |
性質
| 熔點 | 92 °C |
| 比旋光 [α]D | 52° (C=0.2,CHCl3) |
| 溶解性（可溶於） | Acetone |
GHS
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
An Intermediate in the Synthesis of Ezetimibe
This reagent is an intermediate in the synthesis of ezetimibe, which is a selective acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor used in hypercholesterolemia.
References
- Process for preparing Ezetimibe intermediate by an acid enhanced chemo- and enantioselective CBS catalyzed ketone reduction
- Process for preparing Ezetimibe intermediate by enantioselective CBS catalyzed ketone reduction with BH3-DEA prepared in situ
- Burkholderia cenocepacia: a new biocatalyst for efficient bioreduction of ezetimibe intermediate
- Lipase catalyzed kinetic resolution for the production of (S)-3-[5-(4-fluoro-phenyl)-5-hydroxy-pentanoyl]-4-phenyloxazolidin-2-one: An intermediate for the synthesis of ezetimibe
考研文獻
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產品規格
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