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CAS RN: 58-14-0 | 產品號碼: P2037
| 產品號碼 | P2037 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__2H__1__3ClN__4 = 248.71 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 58-14-0 |
| Reaxys-RN | 219864 |
| PubChem Substance ID | 253660065 |
| Merck Index(14) | 7985 |
| MDL編號 | MFCD00057350 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 239.0 to 243.0 °C |
性質
| 熔點 | 241 °C |
| Maximum Wavelength | 276 nm |
| 水溶性 | Insoluble |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H411 : Toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | UV8140000 |
運輸資料
| UN編號 | UN3077 |
| 類別 | 9 |
| 包裝類別 | III |
| HS編碼* | 2933.59-000 |
Application
Pyrimethamine, an inhibitor of dihydrofolate reductase
Pyrimethamine is known as an antagonist of folic acid and has an anti-malarial effect. It inhibits dihydrofolate reductase of bacteria and protozoa and affects cell division by inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid. Its inhibitory effect against human’s dihydrofolate reductase is only 1/1000 in comparison to that of bacteria or protozoa, so that it is considered to be less effective for human. (The product is for research purpose only.)
Related product
Sulfadiazine (S0579)
Related product
Sulfadiazine (S0579)
References
- A 2 : 4-Diamino Pyrimidine in the Treatment of Proguanil-resistant Laboratory Malarial Strains
- Toxoplasmosis (a review)
- Antimalarial compounds: from bench to bedside (a review)
- Effectiveness of Antimalarial Drugs (a review)
考研文獻
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