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CAS RN: 101-26-8 | 產品號碼: P1339
Pyridostigmine Bromide
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產品號碼 | P1339 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__9H__1__3BrN__2O__2 = 261.12 |
外觀與形狀(20°C) | Solid |
儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Hygroscopic |
CAS RN | 101-26-8 |
相關CAS RN | 155-97-5 |
Reaxys-RN | 3764573 |
PubChem Substance ID | 87575426 |
Merck Index(14) | 7977 |
MDL編號 | MFCD00079283 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 153.0 to 157.0 °C |
NMR | confirm to structure |
性質
熔點 | 154 °C |
水溶性 | Soluble |
溶解性(可溶於) | Alcohol |
溶解性(不溶於) | Ether, Acetone, Benzene |
GHS
圖形表示 | |
信號詞 | Danger |
危險性說明 | H300 : Fatal if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
RTECS # | UU5270000 |
運輸資料
UN編號 | UN2811 |
類別 | 6.1 |
包裝類別 | II |
HS編碼* | 2933.31-000 |
Application
Pyridostigmine Bromide: A Reversible Cholinesterase Inhibitor
Pyridostigmine bromide is a reversible cholinesterase inhibitor which inhibits the hydrolysis of acetylcholine (ACh) by competitive reversible binding to acetylcholinesterase (AChE). Pyridostigmine bromide is not through to enter the brain in significant amounts, and mainly activates peripheral cholinergic nervous system by increasing the concentration of ACh in the nerve through reversible inhibition of its hydrolysis by AChE. Pyridostigmine bromide is used for symptomatic treatment of myasthenia gravis and has been applied as a prophylaxis against nerve agents. (The product is for research purpose only.)
References
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- Treatment of myasthenia gravis: focus on pyridostigmine
- A validated HPLC method for the determination of pyridostigmine bromide, acetaminophen, acetylsalicylic acid and caffeine in rat plasma and urine
- Adsorptive stripping voltammetric determination of pyridostigmine bromide in bulk, pharmaceutical formulations and biological fluid
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