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CAS RN: 39562-70-4 | 產品號碼: N1186
Nitrendipine
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纯度/分析方法: >98.0%(HPLC)(N)
別名
- 3-Ethyl 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Ethyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Ethyl Methyl Ester
文件：
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| 產品號碼 | N1186 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__1__8H__2__0N__2O__6 = 360.37 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 39562-70-4 |
| Reaxys-RN | 498823 |
| PubChem Substance ID | 468592504 |
| Merck Index(14) | 6576 |
| MDL編號 | MFCD00082255 |
產品規格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 159 °C |
| Maximum Wavelength | 352(MeOH) nm |
| 溶解性（微溶於） | Methanol, Ether |
GHS
相關法規
| RTECS # | US5653000 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Nitrendipine: A Vascular-Selective Dihydropyridine Calcium Channel Antagonist
Nitrendipine is a vascular-selective dihydropyridine calcium channel antagonist that causes vasodilatation by blocking the influx of calcium ions through L-type calcium channels in cell membranes. It is an effective antihypertensive agent and differs from other calcium channel antagonists in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. (The product is for research purpose only.)
References
- Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state
- Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension
- Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
- Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry
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