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CAS RN: 333353-44-9 | 產品號碼: N1090
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 11.70 to 13.00 % |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2933.39-000 |
Application
「CD4ミミック」と呼ばれている小分子HIV-1侵入阻害剤，NBD-556
It has been reported that NBD-556 is a class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors. NBD-556 binds HIV-1 surface glycoprotein gp120 and induces conformational changes which mimic those caused by cellular receptor CD4 binding. Thus, NBD-556 blocks the interaction between HIV-1 gp120 and its CD4. NBD-556 has unfavorable cytotoxic effects for use as drug, and its analogs have been developing. (The product is for research purpose only.)
References
- Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4
- Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120
- Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds
- K. Yoshimura, S. Harada, J. Shibata, M. Hatada, Y. Yamada, C. Ochiai, H. Tamamura, S. Matsushita, J. Virol. 2010, 84, 7558.
- National Institute of Infectious Diseases AIDS Research Center, Yoshimura Project Laboratory Research Topics “Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds”
- K. Yoshimura, S. Harada, J. Shibata, M. Hatada, Y. Yamada, C. Ochiai, H. Tamamura, S. Matsushita, J. Virol. 2010, 84, 7558.
- Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors
- Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity
考研文獻
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