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CAS RN: 63675-72-9 | 產品號碼: N0900
| 產品號碼 | N0900 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__2__0H__2__4N__2O__6 = 388.42 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 63675-72-9 |
| Reaxys-RN | 454188 |
| PubChem Substance ID | 160871273 |
| Merck Index(14) | 6565 |
| MDL編號 | MFCD00478055 |
產品規格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 148.0 to 154.0 °C |
性質
| 熔點 | 153 °C |
| 水溶性 | Insoluble |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
| RTECS # | US7975600 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，
Nisoldipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nisoldipine have a longer duration of action. Nisoldipine is mainly metabolized by CYP3A4 in the liver. In addition, nisoldipine coat-core (CC) has been developed extended-release formulation that provides sustained 24-h blood pressure control. (The product is for research purpose only.)
References
- Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists
- Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine
- Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series
- Clinical pharmacokinetics of nisoldipine coat-core (a review)
考研文獻
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