Maintenance Notice (3:15 - 7:30 AM February 22, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News February 2025 | [Product Highlights] Chemiluminescent Reagents for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
请选择数量
CAS RN: 91421-42-0 | 產品號碼: N0822
9-Nitrocamptothecin
×
![]()
×
| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 100MG |
NT$11,720
|
17 | 20 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | N0822 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__0H__1__5N__3O__6 = 393.36 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 91421-42-0 |
| Reaxys-RN | 5365063 |
| PubChem Substance ID | 87560509 |
| Merck Index(14) | 8288 |
| MDL編號 | MFCD06656294 |
產品規格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2) |
性質
| 熔點 | 268 °C |
| 比旋光 [α]D | 39° (C=0.4,CHCl3:MeOH=8:2) |
GHS
相關法規
運輸資料
| HS編碼* | 2939.79-000 |
Application
水不溶性のトポイソメラーゼ I阻害剤，9-ニトロカンプトテシン (9-NC)
9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.
References
- Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity
- Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin
- Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
- Encapsulation of 9-nitrocamptothecin, a novel anticancer drug, in biodegradable nanoparticles: factorial design, characterization and release kinetics
- The camptothecins (a review)
- Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high- performance liquid chromatography with ultraviolet and fluorescence detection
考研文獻
文章/手冊
TCIMail
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。