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CAS RN: 70458-96-7 | 產品號碼: N0817
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 221 °C |
GHS
相關法規
| RTECS # | VB2005000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
初のフルオロキノロン系合成抗菌剤，ノルフロキサシン
Norfloxacin is the first fluoroquinolone antibacterial reagent which is synthesized from [C2897] with piperazine. Its structure is related to nalidixic acid [N0490] but its potency has been increased by a fluorine atom and by a piperazine moeity. Thereby, norfloxacin has a broad spectrum of activity against both Gram-positive bacteria and Gram-negative bacteria. Norfloxacin and the other fluoroquinolones inhibit bacterial DNA synthesis by inhibiting the enzyme gyrase which catalyzes the operations of the DNA double strand such as opening, under winding, and closing. Fluoroquinolones appear to prevent specifically the resealing of opened DNA strands and thereby act bactericidally.
References
- Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids
- Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model
- Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Norfloxacin (a review of synthesis and physical properties of norfloxacin)
- Quinolone-mediated bacterial death (a review)
- Analysis of fluoroquinolones in biological fluids by high-performance liquid chromatography (a review)
考研文獻
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