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CAS RN: 25137-01-3 | 產品號碼: N0655
Ethyl (R)-(-)-3-Piperidinecarboxylate
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產品規格
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 98.0 % |
| Specific rotation [a]20/D | -1.0 to -2.0 deg(neat) |
| NMR | confirm to structure |
性質
| 沸點 | 110 °C/20 mmHg |
| flp | 90 °C |
| 比重 | 1.02 |
| 比旋光 [α]D | -1.5° (neat) |
| 折射率 | 1.46 |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H227 : Combustible liquid. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P403 + P235 : Store in a well-ventilated place. Keep cool. |
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
GABA再取り込み阻害剤 (R)-(-)-ニペコチン酸のプロドラッグ，(R)-(-)-ニペコチン酸エチル
Ethyl (R)-(-)-nipecotate is a prodrug of (R)-(-)-nipecotic acid [N0654] which is a γ-aminobutyric acid (GABA) reuptake inhibitor.1) In addition, some derivatives of ethyl (R)-(-)-nipecotate have been synthesized and evaluated for their bioactivity.2-4)
References
- 1)Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice
- 2)Orally active and potent inhibitors of γ-aminobutyric acid uptake
- 3)The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate
- 4)Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3
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