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CAS RN: 498-95-3 | 產品號碼: N0420
3-Piperidinecarboxylic Acid
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| 產品號碼 | N0420 |
| 純度/分析方法 | >98.0%(T) |
| 分子式 / 分子量 | C__6H__1__1NO__2 = 129.16 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 498-95-3 |
| Reaxys-RN | 81096 |
| PubChem Substance ID | 87573759 |
| SDBS (AIST Spectral DB) | 4623 |
| Merck Index(14) | 6560 |
| MDL編號 | MFCD00005992 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Water | very faint turbidity |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | TM6125380 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
γ-アミノ酪酸 (GABA) 再取り込み阻害剤，ニペコチン酸
Nipecotic acid is a γ-aminobutyric acid (GABA) reuptake inhibitor in vitro, used in scientific research. Some nipecotic acid prodrugs have been synthesized and evaluated for their bioactivity in vivo. It is reported that the R-enantiomer [N0654] is a more potent inhibitor than the S-enantiomer [N0678] of the uptake of GABA.
References
- Inhibition of GABA uptake in rat brain slices by nipecotic acid, isoxazoles, and related compounds
- Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain
- Fast HPLC estimation of γ-aminobutyric acid in microdialysis perfusates: effect of nipecotic and 3-mercaptopropionic acids
- Synthesis, Stability, and Pharmacological Evaluation of Nipecotic Acid Prodrugs
- GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
考研文獻
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