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CAS RN: 182431-12-5 | 產品號碼: L0298
| 產品號碼 | L0298 |
| 純度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__3__9H__3__7F__6N__3O__2 = 693.73 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 182431-12-5 |
| Reaxys-RN | 13754976 |
| PubChem Substance ID | 354335361 |
| MDL編號 | MFCD16620494 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 142 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
Lomitapide: A Microsomal Triglyceride Transfer Protein (MTP) Inhibitor
Lomitapide (AEGR-733 or BMS-201038) is a microsomal triglyceride transfer protein (MTP) inhibitor. MTP is a lipid transfer protein that resides in the endoplasmic reticulum of hepatocytes and intestinal epithelial cells, and is required for the assembly and secretion of apolipoprotein B (apo B)-containing lipoproteins by the liver and by the intestine. Lomitapide directly binds and inhibits MTP, thereby preventing the assembly of apolipoprotein B-containing lipoproteins in hepatocytes and intestinal epithelial cells. This inhibits the synthesis chylomicros of and very low-density lipoprotein (VLDL). The inhibition of the synthesis of VLDL leads to reduced levels of low-density lipoprotein cholesterol (LDC-C) in plasma. In addition, lomitapide mesylate [CAS: 202914-84-9] is used for clinical. (The product is for research purpose only.)
References
- Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.
- An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits
- Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia (a review)
- Microsomal transfer protein inhibition in humans (a review)
考研文獻
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