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CAS RN: 50264-69-2 | 產品號碼: L0283
Lonidamine
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 250MG |
NT$7,160
|
6 | 1 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | L0283 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__5H__1__0Cl__2N__2O__2 = 321.16 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 50264-69-2 |
| Reaxys-RN | 894483 |
| PubChem Substance ID | 468592141 |
| MDL編號 | MFCD00866285 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 208.0 to 212.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 210 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | NK7886000 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Lonidamine: An Anticancer Agent Acting on Mitochondria
Lonidamine, a derivate of indazole-3-carboxylic acid, was initially developed as an anti-spermatogenic agent. It was later reported to have anticancer activity with a peculiar mechanism of action. Lonidamine has no function on cellular nucleic acids or protein synthesis, whereas acts on mitochondria to induce apoptosis. Thus, lonidamine exerts a powerful inhibitory effect on oxygen consumption, aerobic glycolysis and lactate transport and accumulation of neoplastic cells. Although the clinical development of lonidamine have been discontinued, it has recently attracted attention as a combination agent with other antitumor agents. (The product is for research purpose only.)
References
- Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
- Mechanism of antineoplastic activity of lonidamine
- Reviving lonidamine and 6-diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer therapy
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