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CAS RN: 100986-85-4 | 產品號碼: L0193
| 產品號碼 | L0193 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__8H__2__0FN__3O__4 = 361.37 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| CAS RN | 100986-85-4 |
| Reaxys-RN | 5385660 |
| PubChem Substance ID | 87558890 |
| SDBS (AIST Spectral DB) | 51758 |
| Merck Index(14) | 6771 |
| MDL編號 | MFCD00865049 |
產品規格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 222.0 to 230.0 °C |
| Specific rotation [a]20/D | -63.0 to -70.0 deg(C=5, CHCl3) |
性質
| 熔點 | 224 °C |
| 比旋光 [α]D | -66° (C=5,CHCl3) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | UU8815550 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Levofloxacin: The Active (S)-(-)-Enantiomer of Ofloxacin, Fluoroquinolone Antimicrobial
Levofloxacin, a synthetic fluoroquinolone antimicrobial, is the active (S)-(-)-enantiomer of the racemic drug substance ofloxacin [O0403]. Levofloxacin has broad-spectrum bactericidal activity against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes. The mechanism of action of ofloxacin (and other fluoroquinolone) involves inhibition of bacterial topoisomerase IV and DNA gyrase (topoisomerases II), enzymes required for DNA replication, transcription, repair and recombination. For your reference, [L0238] is a key synthetic intermediate of levofloxacin. (The product is for research purpose only.)
References
- Synthesis and antibacterial activities of optically active ofloxacin
- In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin
- levofloxacin: a review of its antibacterial activity, pharmacokinetics and therapeutic efficacy
- Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin [C2227, C2510]
- Quinolones in 2005: an update (a review)
考研文獻
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