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CAS RN: 139298-40-1 | 產品號碼: K0055
產品號碼 | K0055 |
純度/分析方法 | >98.0%(HPLC) |
分子式 / 分子量 | C__2__6H__2__9ClN__2O__4S = 501.04 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
應避免的情況 | Heat Sensitive |
包裝和容器 | 5MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 139298-40-1 |
Reaxys-RN | 8357363 |
PubChem Substance ID | 354335639 |
MDL編號 | MFCD00236424 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Elemental analysis(Nitrogen) | 5.00 to 6.00 % |
NMR | confirm to structure |
性質
GHS
相關法規
RTECS # | DB1576070 |
運輸資料
HS編碼* | 2935.90-000 |
Application
KN-93: A Potent and Specific Inhibitor of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
KN-93 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) which is a multifunctional serine/threonine kinase with numerous roles in human physiology. CaMKII mediates immediate effects due to phosphorylation of cellular proteins such as ion channels and calcium handling proteins.
References
- The newly synthesized selective calcium/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
- Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
- NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
- Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure
考研文獻
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