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CAS RN: 160003-66-7 | 產品號碼: I1218
| 產品號碼 | I1218 |
| 純度/分析方法 | >98.0%(GC) |
| 分子式 / 分子量 | C__7H__5IN__2O__3 = 292.03 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 160003-66-7 |
| Reaxys-RN | 7704659 |
| MDL編號 | MFCD11110639 |
產品規格
| Appearance | White to Yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 155 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
運輸資料
| HS編碼* | 2924.29-000 |
Application
Iniparib: A Compound once thought to be a PARP Inhibitor
Poly(ADP-ribose) polymerase (PARP) is a critical enzyme involved in a number of cellular processes including DNA repair, genomic stability and programmed cell death. Inhibition of PARP enzymes has been reported as a potential therapeutic strategy in cancers with specific DNA repair defects.1) Iniparib was originally discovered as a PARP-1 inhibitor for the treatment of triple-negative breast cancer. However, recent studies indicate that iniparib is not a PARP-1 inhibitor.1-4) (The product is for research purpose only.)
References
- 1) Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors (a review)
- 2) Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro
- 3) Appraising iniparib, the PARP inhibitor that never was-what must we learn?
- J. Mateo, M. Ong, D. S. P. Tan, M. A. Gonzalez, J. S. de Bono, Nat. Rev. Clin. Oncol. 2013, 10, 688.
- 4) Target engagement imaging of PARP inhibitors in small-cell lung cancer
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