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CAS RN: 172152-36-2 | 產品號碼: I1191
| 產品號碼 | I1191 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__1__8N__4O__2S = 366.44 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 172152-36-2 |
| Reaxys-RN | 8859737 |
| MDL編號 | MFCD00942538 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 151 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
Ilaprazole: A Proton Pump Inhibitor with Superior Pharmacological Profile
Ilaprazole (IY-81149) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD) and duodenal ulcer in clinical.1,2) Compared with all other PPIs, ilaprazole has shown an extended plasma half-life, a metabolism not significantly influenced by CYP2C19 genetic polymorphism and similar safety.2) Ilaprazole can be used with clarithromycin [C2220] and amoxicillin [A2099] as a triple therapy regimen for eradicating Helicobacter pylori.3) In addition, there are reports that PPIs including ilaprazole suppresses cancer growth.4) (The product is for research purpose only.)
References
- 1) General pharmacology of IY-81149, a new proton pump inhibitor
- 2) Ilaprazole for the treatment of gastro-esophageal reflux (a review)
- 3) Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study
- 4) Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase.
- 5) Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review
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