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CAS RN: 53179-09-2 | 產品號碼: I1049
Sisomicin Sulfate
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| 產品號碼 | I1049 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__9H__3__7N__5O__7·2^^1/__2H__2SO__4 = 692.71 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 53179-09-2 |
| 相關CAS RN | 32385-11-8 |
| Reaxys-RN | 5709343 |
| PubChem Substance ID | 354335157 |
| Merck Index(14) | 8550 |
| MDL編號 | MFCD00058308 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +98.0 to +104.0 deg(C=1, H2O) |
性質
| 熔點 | 73 °C |
| 沸點 | 155 °C |
| 比旋光 [α]D | 100° (C=1,H2O) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
運輸資料
| HS編碼* | 2941.90-000 |
Application
Sisomicin Sulfate: An Aminoglycoside Antibiotic that is Effective against Pseudomonas aeruginosa
Sisomicin sulfate is a naturally occurring aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is bactericidal in action against a wide range of Gram-negative and Gram-positive bacteria, including Klebsiella species, Escherichia coli, Pseudomonas aeruginosa, Enterobacter species, and Proteus species. Sisomicin is closely related structurally to gentamicin [G0383], but in vitro studies have shown it to have superior activity to gentamicin against Pseudomonas aeruginosa. Sisomicin, like that of the other aminoglycoside antibiotics, binds the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of transcription. Consequently, bacterial protein synthesis is inhibited. (The product is for research purpose only.)
References
- Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus
- Sisomicin, netilmicin and dibekacin: a review of their antibacterial activity and therapeutic use
- Sisomicin: an aminoglycoside antibiotic that is highly effective against Pseudomonas (a review)
- High-performance liquid chromatographic analysis of aminoglycoside antibiotics
考研文獻
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