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CAS RN: 3778-73-2 | 產品號碼: I0713
| 產品號碼 | I0713 |
| 純度/分析方法 | >95.0%(GC)(T) |
| 分子式 / 分子量 | C__7H__1__5Cl__2N__2O__2P = 261.08 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 3778-73-2 |
| Reaxys-RN | 5802893 |
| PubChem Substance ID | 468592053 |
| Merck Index(14) | 4896 |
| MDL編號 | MFCD00057374 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 44.0 to 50.0 °C |
| Specific rotation | -1.0 to +1.0 deg(C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 48 °C |
| 水溶性 | Soluble |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | RP6050000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2934.99-000 |
Application
Ifosfamide: An Oxazophosphorine Antitumor Alkylating Agent
Ifosfamide is an oxazaphosphorine alkylating agent with a broad spectrum of antineoplastic activity. It is a prodrug that requires metabolic activation by hepatic cytochrome P450 isoenzymes to exert its cytotoxic activity. The exact mechanism of action of ifosfamide has not been determined, but among various metabolites, isophosphoramide mustard probably represents the most important cytotoxic compound able to produce irreparable cross-links between DNA strands caused by alkylation by the isophosphoramide mustard at guanine N-7 positions. In addition, mesna [M0913] is often used as a prophylactic agent for side effects of oxazophosphorine antitumor alkylating agents such as cyclophosphamide [C2236] and ifosfamide. (The product is for research purpose only.)
References
- Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer.
- Pharmacology of ifosfamide (a review)
- Simultaneous determination of cyclophosphamide, ifosfamide, doxorubicin, epirubicin and daunorubicin in human urine using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry: bioanalytical method validation
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