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CAS RN: 74-88-4 | 產品號碼: I0060
Iodomethane (stabilized with Copper chip)
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* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | I0060 |
| 純度/分析方法 | >99.5%(GC) |
| 分子式 / 分子量 | CH__3I = 141.94 |
| 外觀與形狀（20°C） | Liquid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Moisture Sensitive |
| CAS RN | 74-88-4 |
| Reaxys-RN | 969135 |
| PubChem Substance ID | 125309537 |
| SDBS (AIST Spectral DB) | 3048 |
| Merck Index(14) | 6087 |
| MDL編號 | MFCD00001073 |
產品規格
| Appearance | Colorless to Almost colorlessclear liquid |
| Purity(GC) | min. 99.5 % |
性質
| 沸點 | 43 °C |
| 比重 | 2.28 |
| 折射率 | 1.53 |
| 水溶性 | Slightly soluble |
| Degree of solubility in water | 14 g/l 20 °C |
| 溶解性（可與之混溶） | Alcohol, Ether |
| 溶解性（可溶於） | Acetone |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H330 : Fatal if inhaled. H301 : Toxic if swallowed. H315 : Causes skin irritation. H318 : Causes serious eye damage. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H373 : May cause damage to organs through prolonged or repeated exposure. H351 : Suspected of causing cancer. H335 : May cause respiratory irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P260 : Do not breathe mist or vapours. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | PA9450000 |
運輸資料
| UN編號 | UN2644 |
| 類別 | 6.1 |
| 包裝類別 | I |
| 航空運輸 | Forbidden for Air Transport |
| HS編碼* | 2903.69-000 |
Application
Methylation of Carboxylic Acids
References
- W. Craig, J. Chen, D. Richardson, R. Thorpe, Y. Yuan, Org. Lett. 2015, 17, 4620.
- S. Dhanasekaran, V. Bisai, R. A. Unhale, A. Suneja, V. K. Singh, Org. Lett. 2014, 16, 6068.
Application
Olefin Synthesis through Chugaev Elimination
Typical Procedure:
To a stirred solution of alcohol 1 (100 mg, 0.25 mmol) in THF (20 mL) is added 60% NaH (100 mg,) at 0 ℃. The reaction mixture is stirred for 2 h, followed by addition of carbon disulfie (1 mL), and the reaction mixture is stirred for an additional 1.5 h. After this period, MeI (0.5 mL) is added and the reaction mixture is allowed to come to room temperature and stirred overnight. Then ether (20 mL) is added, followed by ice-water (10 mL). The aqueous phase is extracted three times with ether. The combined organic layers are washed with brine, dried, and evaporated. The residue is purified by flash chromatography (AcOEt : Petroleum Ether = 1 : 9) to give 2 (61 mg, 0.13 mmol, Y. 51%) as a colorless oil. A solution of degassed and freshly distilled dodecane (5 mL) and 2 (61 mg, 0.13 mmol) is refluxed for 48 h at 216 ℃. Then the solvent is evaporated until 1 mL of the volume remained, followed by flash chromatography (AcOEt : Petroleum Ether = 1 : 9) to give 3 (35 mg, Y. 74%) as a colorless oil.
To a stirred solution of alcohol 1 (100 mg, 0.25 mmol) in THF (20 mL) is added 60% NaH (100 mg,) at 0 ℃. The reaction mixture is stirred for 2 h, followed by addition of carbon disulfie (1 mL), and the reaction mixture is stirred for an additional 1.5 h. After this period, MeI (0.5 mL) is added and the reaction mixture is allowed to come to room temperature and stirred overnight. Then ether (20 mL) is added, followed by ice-water (10 mL). The aqueous phase is extracted three times with ether. The combined organic layers are washed with brine, dried, and evaporated. The residue is purified by flash chromatography (AcOEt : Petroleum Ether = 1 : 9) to give 2 (61 mg, 0.13 mmol, Y. 51%) as a colorless oil. A solution of degassed and freshly distilled dodecane (5 mL) and 2 (61 mg, 0.13 mmol) is refluxed for 48 h at 216 ℃. Then the solvent is evaporated until 1 mL of the volume remained, followed by flash chromatography (AcOEt : Petroleum Ether = 1 : 9) to give 3 (35 mg, Y. 74%) as a colorless oil.
References
- Total Synthesis of Dihydroclerodin from (R)-(-)-Carvone
Application
Methylation of Alcohols using Methyl Iodide
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Methylation of Alcohols using Silver(I) Oxide and Methyl Iodide
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Methylation of Alcohols using Silver(II) Oxide and Methyl Iodide
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
Methylation of Alcohols using Silver(I) Triflate and Methyl Iodide
Reference
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
考研文獻
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