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CAS RN: 3258-02-4 | 產品號碼: H1803
N4-Hydroxycytidine
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| 產品號碼 | H1803 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__9H__1__3N__3O__6 = 259.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 3258-02-4 |
| Reaxys-RN | 32372 |
| MDL編號 | MFCD01675695 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
| RTECS # | YU8080000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Inhibitor Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase
References
- β-D-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome
- Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
Application
N4-Hydroxycytidine: A Potent and Selective Viral RNA-Dependent RNA polymerase (RdRp) Inhibitor
N4-Hydroxycytidine (EIDD-1931), an antiviral ribonucleoside analog, is an active metabolite of molnupiravir which has activity against a number of RNA viruses.1,2) The RNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for RNA virus replication processes and catalyzes the replication of RNA from an RNA template.3) Because of this, they are often recognized as good targets for antiviral agents. It has been reported that N4-hydroxycytidine acts as a viral RdRp inhibitor of RNA viruses.1,4,5) (The product is for research purpose only.)
References
- 1) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- 2) Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2
- 3) RNA dependent RNA polymerases: insights from structure, function and evolution
- 4) β-D-N4-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome
- 5) Small-molecule antiviral β-D-N4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance
TCIMail
[Featured Products] RNA-dependent RNA Polymerase Inhibitors[Product Highlights] Antiviral Reagent Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase
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