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CAS RN: 278779-30-9 | 產品號碼: G0648
| 產品號碼 | G0648 |
| 純度/分析方法 | >95.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__2__8H__2__2Cl__3NO__4 = 542.84 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 278779-30-9 |
| Reaxys-RN | 10125635 |
| MDL編號 | MFCD09971006 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 173.0 to 177.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 175 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
GW 6064: The First Non-Steroidal and Selective Farnesoid X Receptor (FXR) Agonist
The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor (BAR) expressed primarily in the liver and intestine.1) FXR plays important roles not only in bile acid, lipid metabolism, and carbohydrate homeostasis, but also in inflammatory responses.2) GW 6064 is the first non-steroidal and selective FXR agonist with decent submicromolar potency and has been used to study the role of FXR in dyslipidemia, diabetes, obesity and cancer.2,3) (The product is for research purpose only.)
References
- 1) Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets
- 2) Role of farnesoid X receptor in inflammation and resolution (a review)
- 3) Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
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