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CAS RN: 180200-66-2 | 產品號碼: G0627
Gatifloxacin Sesquihydrate
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| 產品號碼 | G0627 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__2__2FN__3O__4·1^^1/__2H__2O = 402.42 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 180200-66-2 |
| Reaxys-RN | 14390028 |
| MDL編號 | MFCD22373645 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 179.0 to 183.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 181 °C |
GHS
相關法規
| RTECS # | VB1983650 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
Gatifloxacin: An 8-Methoxy Fluoroquinolone Antibacterial Agent with a Broad Antibacterial Spectrum
Gatifloxacin (AM-1155) is an 8-methoxy fluoroquinolone antibacterial agent with a 3-methylpiperazinyl substituent at C7. Fluoroquinolone fungicidal antibacterial agents are inhibitors of bacterial DNA gyrase and topoisomerase IV.1,2) DNA gyrase is an essential enzyme involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the division of chromosomal DNA during bacterial cell division. As just described, the mechanism of action of fluoroquinolones is different from that of other antibiotics. Therefore, there is no cross-resistance between fluoroquinolones and the other classes of antibiotics. In particular, gatifloxacin has a broader spectrum of antibacterial activity than the older fluoroquinolones and shows good activity against many Gram-positive and Gram-negative bacteria, atypical organisms and some anaerobes.3) In addition, gatifloxacin has higher selectivity for bacterial type II topoisomerases.4) (The product is for research purpose only.)
References
- 1) In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinoline
- 2) Quinolone-mediated bacterial death (a review)
- 3) Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin
- 4) Inhibitory Activities of Gatifloxacin (AM-1155), a Newly Developed Fluoroquinolone, against Bacterial and Mammalian Type II Topoisomerases
- 5) Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma
- 6) Gatifloxacin (a review)
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